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Objective: To explore evaluation effect of three-dimensional speckle tracking imaging (3D-STI) on left ventricular systolic function in patients with acute anterior myocardial infarction (AAMI).Methods: A total of 40 AAMI patients and 40 healthy subjects were enrolled as AAMI group and healthy control group respectively.Left ventricular longitudinal strain (LS), radial strain (RS), circumferential strain (CS), area of strain (AS), general longitudinal strain (GLS), general radial strain (GRS), general circumferential strain (GCS) and general area of strain (GAS) were measured, compared and analyzed between two groups for 3D-STI technique.Results: Compared with healthy control group, there were significant reductions in left ventricular LS of 12/17 segment, RS and AS of 10/17 segment, and CS of 9/17 segment in AAMI group, P<0.05 or <0.01;for general strain values, compared with healthy control group, there were significant reductions in GLS[(19.59±3.52) vs.(9.25±2.16)], GRS[(36.73±4.83) vs.(25.26±5.19)], GCS[(22.63±4.38) vs.(15.15±3.98)], GAS[(32.87±4.41) vs.(21.73±3.84)]in AAMI group, P<0.01 all.Conclusion: The three-dimensional speckle tracking imaging can accurately detect segmental myocardial strains of left ventricular systolic function in patients with acute anterior myocardial infarction.It can be used as a quantitative measure for clinical evaluation of these patients′ condition.
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Objective To evaluate left ventricular(LV) twist and untwist using velocity vector imaging(VVI) in patients with apical hypertrophic cardiomyopathy (ApHCM). Methods Twenty-three patients diagnosed with ApHCM were consecutively enrolled and compared with normal controls. After a standard echocardiographic examination, parasternal basal and apical short-axis planes were scanned to quantify LV rotations,twist and LV untwist using VVI. Results Compared with the normal controls, the rotation and rotaional velocity of apical subendocardial myocardium were markedly decreased in ApHCM patients during the period of systole ( P＜0.05) ,but the decreases in basal planes were not significant. As a consequence,LV twist was significantly lower in ApHCM patients (P＜ 0.05). Compared to normal controls,the velocity of LV untwisting was also significantly decreased in ApHCM patients ( P＜0.05).Conclusions The twist and untwist of LV subendocardial myocardium were decreased in ApHCM patients.VVI is a useful method to assess the characteristics of LV twist and untwist in ApHCM patients.
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nd targeted-ultrasound can facilitate VEGF gene transfer of vascular endothelial. Targeted-ultrasound group transfer efficiency is higher than that of microbubble group, and the plasmid alone can not promote transfer of vascular endothelial.
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Objective To seek a new method to identify viability of myocardium by adenosine stress echocardiography combined with quantitative tissue velocity imaging(QTVI)and tissue tracking(TT).Methods Fifteen healthy canines were selected to establish the models of acute myocardial infarction and reperfusion by ligating anterior descending branch of coronary artery for 90 minutes and then releasing the artery to get reperfusion.After reperfusion.peak velocity in systole(Vs),peak velocity in isovolumic contraction(VIVC)and the displacement in systole(Ds)were measured on anterior wall and anterior septum at baseline.The 2,3,5-triphenyl tetrazolium chloride(TTC)staining was set as a"gold standard"for defining the viable and non-viable groups.The sensitivity and specificity of assessing myocardial viability were determined with QTVI and TT.Comparison of variables between viable and non-viable group was made by using t test.One way analysis of variance and LSD-t test were used to estimate the significance of differences in different states.Results Compared with baseline,Vs,VIVC and Ds decreased significantly(P＜0.01)after reperfusion in both viable and non-viable group.After administration of adenosine,Vs and Ds increased(P＜0.05),but VIVC didn't change significantly compared with that before administration of adenosine in viable group(P＞0.05).Variables in non-viable group didn't change significantly after administration of adenosine(P＞0.05).By receiver operating characteristic(ROC)analysis for predicting myocardial viability,when a cutoff value of △Vs(%)rate was 17.9,the sensitivity and the specificity was 78.6%and 81.1%,respectively,and when the cutoff value of △Ds(%)rate was 18.4,the sensitivity and the specificity was 75.0%,83.6%,respectively.Combined △Vs(%)with △Ds(%),the sensitivity and specificity to prediction of myocardium viability could reach 94.6%and 68.0%,respectively.Conclusions When the viability of myocardium after myocardial infarction is assessed by using the method of adenosine stress echocardiography with QTVI and TT,the sensitivity and the specificity are greatly enhanced.